Mission

Mid-Infrared Silicon Photonic Sensors for Healthcare and Environmental Monitoring

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MISSION unites a team of photonics engineers, healthcare clinicians and oceanographers, set to develop the next generation of photonics technology that will enable rapid diagnostic medical screening and environmental monitoring.

Silicon photonics has transformed data communications technology thanks to its low cost and high performance. MISSION’s aim is to bring the benefits of this technology to a range of new applications that could be manufactured at a mass scale to solve societal challenges and transform peoples’ lives.

Currently silicon photonics applications operate in the near-infrared wavelength range (1.2 μm – 1.6 μm). Key to this project will be the development of chip-scale sensors in the mid-infrared wavelengths (3-15μm); this is known as the “fingerprint region” as it enables sensors to spot unique identifiers in biological and chemical molecules. Research leaders from the Universities of Southampton, Sheffield and York, the University Hospital Southampton and the National Oceanography Centre will utilise their world leading expertise in photonics, electronics, sensing and packaging to unleash the full potential of integrated MIR photonics. Realising low cost, mass manufacturable devices and circuits for biomedical and environmental sensing, and subsequently improve performance by on-chip integration with sources, detectors, microfluidic channels, and readout circuits and build demonstrators to highlight the versatility of the technology in important application areas.

Our work packages

Platforms and components

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We will demonstrate broadband Si and Ge-based passive devices (splitters, couplers, resonators, interferometers) with low insertion loss in the 3-14µm range. Such devices will utilise our unique suspended Si and Ge approach based on subwavelength grating (SWG) claddings, using the full transparency ranges of Si and Ge. We will optimise mechanical integrity and the application of suitable claddings and optimised phase shifters for MIR sensor development. To date, Si and Ge MIR chips have been fabricated using e-beam lithography, but for mass manufacturing compatibility, it is important to address wafer scale fabrication using our deep UV (DUV) lithography system. We will also develop a novel “on-chip integrating sphere” geometry both in Si and Ge that promises ultralong interaction lengths. To improve signal-to-noise (S/N) ratio we will develop Si and Ge photonic circuits with on-chip referencing and on-chip modulation.

Sources and detectors

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We will develop a range of devices for integration with Si and Ge platforms to enable on-chip spectroscopy and sensing. We will develop quantum and interband cascade lasers (QCL, ICL) with broad tuning range and will use optimised integration techniques including elastomer stamp transfer and flip-chip transfer for integration into waveguide-based spectrometers. We will also investigate ICL/QCL-based on-chip mid-IR frequency combs, that will enable on-chip versions of comb–based spectroscopic methods that have demonstrated high resolution/sensitivity and fast parallel acquisition times in benchtop applications. We will also explore broad-band spectroscopic techniques based on MIR intraband LEDs which have recently shown excellent power and bandwidth properties. In terms of detectors, we will work on novel room temperature waveguide microbolometers that can be wavelength-selective and highly sensitive via resonance enhancement. In addition, III-V detectors will be developed for Si and Ge photonic circuits.

Sample processing and delivery

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We will enhance specificity and sensitivity by novel integration of microfluidics and functional polymer layers with Si and Ge chips, including analyte enrichment driven by partition ratios between liquid-liquid and liquid-solid interfaces. For example, we will explore the use of polymers with intrinsic microporosity and doping with molecular cages for filtering or pre-concentrating gas samples. Both can be deposited on waveguide sensors to locally increase the concentration, thereby improving the limit of detection. We will also investigate integration of phase-separators for microdroplet liquid-liquid enrichment, and extraction of analytes into non-absorbing solvents to remove water absorption in the MIR. To interface with optical elements, we will explore both a fully integrated approach, with all elements on a single carrier, and an approach whereby light is coupled into a separate microfluidic sensor chip.

Integration, electronics and packaging

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We will integrate and package components (sources/detectors, sensor components, Si and Ge chips, and sample delivery systems) and develop electronic to produce modular systems at TRL3 for functional demonstrators. Packaging (including demonstrators) will maximise robustness (particularly to vibration, fluids / particles and wide temperature / pressure variations) at the component and system level by investigating materials, interface bonding strategies, encapsulation, and mechanical design innovations (e.g. compliance, fluid encapsulation). Focus will be maintained on research by utilising existing technology.

Applications

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We will bring together the components and systems to showcase versatility of the technologies developed in MISSION, we have identified 3 demonstrators: 1) identification and quantification of therapeutic drugs in blood at clinically relevant concentrations using Si/Ge chips and integrated sample delivery systems; 2) liquid biopsy – protein sensing for detection of cancer; 3) detection of gases (e.g. CO2, CH4, N2O) in oceans / aquatic environments with climate relevant performance using Si/Ge chips with integrated sources, detectors and electronics, long interaction lengths and enrichment in functionalised membranes, with robust packaging.

Latest news

Keep up to date with the latest news from MISSION.

“MISSION is an ambitious and highly innovative programme exploiting Silicon Photonics for new and challenging applications and brings together multiple academic, health care and industry partners.

The leadership team is a considerable strength, consisting of world-renowned researchers from a diverse range of fields that have come together to address the goals of this EPSRC programme grant.

It is clear that the team is defining best-practice for the necessary level of interaction required by this cross-disciplinary research programme.

The research activities are conducted by an impressive group of post-doctoral researchers and graduate students, and the team spirit amongst these early career researchers enables the highest quality of the work. I look forward to continued interaction with this ground-breaking team.”

Prof Andy Knights
Associate Vice-President, Research, McMaster University

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